CD47

CD47
已知的結構 PDB 直系同源搜索: PDBe RCSB PDBID列表 2JJS、​2JJT、​2VSC、​4CMM、​4KJY、​5IWL
識別號
别名	CD47；, IAP, MER6, OA3, CD47 molecule
外部ID	OMIM：601028 MGI：96617 HomoloGene：1346 GeneCards：CD47
基因位置（人类） 染色体 3號染色體[1] 基因座 3q13.12 起始 108,043,091 bp[1] 终止 108,091,862 bp[1]
基因位置（小鼠） 染色体 小鼠16号染色体[2] 基因座 16|16 B5 起始 49,620,896 bp[2] 终止 49,735,373 bp[2]
RNA表达模式
查阅更多表达数据
基因本體 分子功能 • thrombospondin receptor activity • 血浆蛋白结合 • protein binding involved in heterotypic cell-cell adhesion • cell-cell adhesion mediator activity 細胞組分 • integral component of membrane • 细胞膜 • integral component of plasma membrane • 膜 • specific granule membrane • tertiary granule membrane • 外排體 • cell surface 生物學過程 • integrin-mediated signaling pathway • positive regulation of phagocytosis • 細胞粘附 • extracellular matrix organization • positive regulation of inflammatory response • positive regulation of T cell activation • response to bacterium • leukocyte migration • positive regulation of cell population proliferation • opsonization • positive regulation of cell-cell adhesion • neutrophil degranulation • 细胞迁移 • regulation of interferon-gamma production • regulation of interleukin-10 production • regulation of interleukin-12 production • regulation of interleukin-6 production • regulation of tumor necrosis factor production • heterotypic cell-cell adhesion • monocyte extravasation • regulation of nitric oxide biosynthetic process • positive regulation of stress fiber assembly • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to interleukin-12 • cell-cell adhesion • negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Sources:Amigo / QuickGO
直系同源
物種	人類	小鼠
Entrez	961	16423
Ensembl	ENSG00000196776	ENSMUSG00000055447
UniProt	Q08722	Q61735
mRNA​序列	NM_001025079 ​NM_001025080 ​NM_001777 ​NM_198793 ​NM_001382306	NM_010581 ​NM_001368415 ​NM_001368416 ​NM_001368417 ​NM_001368418
蛋白序列	NP_001768 ​NP_942088 ​NP_001369235	NP_034711 ​NP_001355344 ​NP_001355345 ​NP_001355346 ​NP_001355347
基因位置​（UCSC）	Chr 3: 108.04 – 108.09 Mb	Chr 16: 49.62 – 49.74 Mb
PubMed​查找	[3]	[4]
維基數據
檢視/編輯人類 檢視/編輯小鼠

CD47，也称整联素关联蛋白（IAP），是在人体中由CD47基因编码的跨膜蛋白。它属于免疫球蛋白超家族^[5]，可以与整联蛋白、血小板反应素（TSP-1）以及信号调节蛋白α（SIRPα）相互作用^[6]。CD-47作为一种可防止巨噬细胞吞噬的信号分子，具有作为某些癌症的治疗靶点的潜力，最新研究表明其也可能与肺纤维化有关^[7]。

CD47参与了一系列的细胞活动，包括凋亡、增殖、黏着与迁移，而且还在免疫和血管新生响应中发挥着重要作用。CD47在人体细胞中广泛表达，并且在多种不同的癌细胞中是过表达的^[6][8]。

1. ^ ^{1.0 1.1 1.2} GRCh38: Ensembl release 89: ENSG00000196776 - Ensembl, May 2017
2. ^ ^{2.0 2.1 2.2} GRCm38: Ensembl release 89: ENSMUSG00000055447 - Ensembl, May 2017
3. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
4. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
5. ^ CD47 CD47 molecule [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. [2018-10-17]. （原始内容存档于2019-09-24） （英语）. 
6. ^ ^{6.0 6.1} Sick, E; Jeanne, A; Schneider, C; Dedieu, S; Takeda, K; Martiny, L. CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest. British Journal of Pharmacology. 2012-11-06, 167 (7): 1415–1430. ISSN 0007-1188. PMC 3514757 . PMID 22774848. doi:10.1111/j.1476-5381.2012.02099.x （英语）. 
7. ^ Fibrosis reversed when 'don't eat me' signal blocked, study finds. [2018-10-17]. （原始内容存档于2018-10-17）. 
8. ^ Chao, Mark P.; Weissman, Irving L.; Majeti, Ravindra. The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications. Current Opinion in Immunology. 2012-4, 24 (2): 225–232 [2018-10-17]. ISSN 1879-0372. PMC 3319521 . PMID 22310103. doi:10.1016/j.coi.2012.01.010. （原始内容存档于2018-10-17）.  请检查|date=中的日期值 (帮助)